MOTS-c 10mg · Mitochondrial-Derived Peptide

Compound Profile

Researcher-grade specs. No guesswork.

Each vial ships with the structural data and lot identifiers researchers need for traceable, reproducible work.

Built for the bench.

Synthesized via solid-phase peptide chemistry, purified by reverse-phase HPLC, verified by mass spectrometry, and tested for sterility and endotoxin load. Every spec below is documented on the signed Certificate of Analysis that ships with your vial.

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Compound

MOTS-c

Class

Mitochondrial-derived (16-AA)

Sequence

MRWQEMGYIFYPRKLR

CAS Number

1627580-64-6

Molecular Formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

Molecular Weight

2174.6 g/mol

Concentration

10 mg / vial

Form

White powder

Purity (HPLC)

≥ 99%

Identity (LC-MS)

Confirmed

Storage

2-8°C, sealed, dry

Origin

Made in the USA

In the Literature

What researchers are studying.

A short, sourced summary of where MOTS-c appears in the published research record. For context only. Not a claim, not a protocol, not advice.

MOTS-c (Mitochondrial Open Reading frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded by the mitochondrial genome itself rather than the nuclear genome. It is one of the first identified members of the mitochondrial-derived peptide (MDP) family.

In published preclinical literature, MOTS-c has been investigated for its role in cellular energy metabolism via the AMPK pathway, with studies examining glucose uptake, insulin sensitivity, and metabolic homeostasis in rodent models. Plasma MOTS-c concentrations have been documented to decline with age in human studies, which has driven academic interest in its biology.

The peptide is most-cited alongside investigations of AMPK activation, mitochondrial bioenergetics, exercise physiology, and obesity / insulin-resistance models. It has not been approved by the FDA for any therapeutic indication and remains classified as a research compound.

For research use only. Statements above describe published research literature and do not constitute health, medical, or therapeutic claims. Not for human or veterinary use. Not evaluated by the FDA.

Documented Research Areas

AMPK pathway activation and cellular energy sensing
Glucose uptake and insulin sensitivity (rodent models)
Mitochondrial bioenergetics and oxidative phosphorylation
High-fat-diet-induced obesity and metabolic homeostasis
Exercise physiology and skeletal muscle research
Aging biology and plasma MOTS-c decline studies

Selected Studies · Peer-Reviewed Literature

A curated list of published peer-reviewed papers indexed in PubMed where MOTS-c has been studied. Provided for research-context only. Linking to the literature does not constitute endorsement of any therapeutic application.

Lee C, et al. (2015) · Cell Metab The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance PubMed · 25738459
Reynolds JC, et al. (2021) · Nat Commun MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis PubMed · 33420074
Lu H, et al. (2019) · Nutrients Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation PubMed · 31487909
Kim SJ, et al. (2018) · Aging Cell Mitochondrially derived peptides as novel regulators of metabolism PubMed · 28758334
Ramanjaneya M, et al. (2019) · J Endocr Soc Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects PubMed · 31119263
Lu H, et al. (2019) · FASEB J MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction PubMed · 30725119
Yan Z, et al. (2023) · Front Endocrinol MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation PubMed · 37152961
D'Souza RF, et al. (2020) · Aging Circulatory and muscle-localized exercise-induced mitochondrial-derived peptide MOTS-c is an age-dependent biomarker of musculoskeletal aging PubMed · 32213657

Transparency

Every lot. Every researcher. Same proof.

Each batch ships with a third-party Certificate of Analysis from BioRegen Analytical. HPLC purity, mass-spectrometry identity, sterility, and LAL endotoxin screening. Every test, every lot.

Your lot number ships on the label and on the COA. Enter it in the verifier any time to retrieve the original lab report.

Verify Your Batch Download Sample COA

Certificate of Analysis

BioRegen Analytical · Independent Lab · Lot #11653

CompoundMOTS-c

CAS#1627580-64-6

FormulaC₁₀₁H₁₅₂N₂₈O₂₂S₂

Mol. Weight2174.6 g/mol

Identity (LC-MS)PASS · 710.36 m/z

Purity (HPLC)99.72%

Retention Time3.68 min

Sterility / LALPASS

Date Tested2026-04-12

Sample · Live data on verifier

Pairs With

Related compounds.

Other research peptides in the Elixser catalog cited alongside MOTS-c in the published research literature.

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Common Questions

Answered straight.

MOTS-c is one of the first identified mitochondrial-derived peptides (MDPs) — peptides encoded by the mitochondrial genome rather than by nuclear DNA. The 16-amino-acid sequence (MRWQEMGYIFYPRKLR) is read from the 12S rRNA region of the mitochondrial DNA and translated within the mitochondrion itself. Most other research peptides are nuclear-encoded; MDPs are a relatively new class with distinct biology. This is part of why MOTS-c is studied separately from other GH-axis or tissue-repair peptides — it sits in a different signaling family.

Mitochondrial Open reading frame of the Twelve S rRNA, type c. The name describes where the peptide-encoding sequence sits in the mitochondrial genome. It was first characterized by the Cohen lab (USC) in 2015.

Every lot is tested by reverse-phase HPLC and certified at ≥99% purity. The Certificate of Analysis lists the exact lot purity (most lots run between 99.5% and 99.9%). Your COA ships with the vial and is also retrievable by lot number through our online verifier.

Testing is done by BioRegen Analytical, an independent third-party lab. Every batch goes through HPLC purity, LC-MS identity confirmation, sterility screening, and LAL endotoxin testing. The signed Certificate of Analysis ships with each vial. Same lot number, same COA, every time.

Made in the USA. Synthesized in a US cGMP-aligned facility. Tested by a US-based independent lab. Shipped from US fulfillment.

Orders ship via 2-day expedited delivery from US fulfillment. Free over $150. Vials are sealed, packaged with insulation, and shipped in tamper-evident packaging. Tracking number is sent the same day your order leaves the warehouse.

30-day money-back guarantee on every order. If a vial arrives damaged, fails to match the COA, or you change your mind within 30 days, contact us and we will refund or replace. No restocking fees, no return shipping cost on defective product.

One sealed 10mg vial of MOTS-c as a white powder. Lot-stamped label. Signed Certificate of Analysis. Tamper-evident packaging. Bacteriostatic water for reconstitution research is sold separately and can be added in the cart.

Store sealed at 2-8°C, away from direct light, heat, and moisture. Sealed shelf life is 24 months from the date on the COA. Once reconstituted for research, store reconstituted material refrigerated and follow standard peptide-handling protocols for your lab.

No. All Elixser Peptides products are sold strictly for laboratory research and in vitro study. They are not drugs, food, or cosmetics. They are not for human or veterinary use, consumption, or therapeutic application. They have not been evaluated by the FDA. By purchasing, you agree to use these materials in compliance with applicable laws and ethical research standards.

Research Use Only

MOTS-c

Researcher-grade specs. No guesswork.

Built for the bench.

What researchers are studying.

Every lot. Every researcher. Same proof.

Related compounds.

Answered straight.

Add MOTS-c 10mg to your research arsenal.